Type 2 diabetes : a revolutionary drug soon to be developed ?

Dietary balance and physical activity. This is usually what doctors recommend as the first line for people with type 2 diabetes.

If this is not enough, it is necessary to switch to antidiabetic treatments, including taking insulin. As this hormone is no longer produced in sufficient quantity by the pancreas, it must be administered in the form of injections in order to help the patient regulate his blood sugar correctly.

Problem : this treatment has many constraints. Above all, it does not treat the cause of diabetes, but its consequences. Hence the strategy of the international team coordinated by Inserm researcher Vincent Marion : to develop new drugs that target the origin of the disease.

The adipose tissue trail

Initial work had enabled French, British, American and Australian researchers to identify a link between insulin resistance, which often precedes the onset of type 2 diabetes (liver, muscle and adipose tissue cells are less sensitive to insulin) and some adipose tissue abnormalities.

The scientists continued on this path and managed to develop a drug that “specifically targets adipocytes by restoring glucose uptake there and thus restoring the metabolic physiology of adipose tissue”.

In other words, by targeting adipocytes, the researchers succeeded in treating insulin resistance, “with beneficial effects on the whole organism”.

Called PATAS, the drug has been successfully tested in diabetic mice, paving the way for an upcoming clinical trial in humans.

Source : https://pubmed.ncbi.nlm.nih.gov/35822820/

What diet for diabetics ?

When it comes to a diet for diabetics, there isn't a one-size-fits-all approach. However, there are some general guidelines that can help manage blood sugar levels and promote overall health. Here are some key points to consider :

- Balanced Meals : Aim for a balanced diet that includes a variety of healthy foods from all food groups. This includes fruits, vegetables, whole grains, lean proteins, low-fat dairy, and healthy fats.

- Carbohydrate Management : Pay attention to the type and amount of carbohydrates you consume, as they can impact blood glucose levels. Choose complex carbohydrates like whole grains, legumes, and vegetables, and limit simple carbohydrates like sugary drinks and sweets.

- Portion Control : Watch your portion sizes to avoid overeating and manage calorie intake. This can help with weight management and blood sugar control.

- Healthy Fats : Include sources of healthy fats in your diet, such as nuts, seeds, avocados, and olive oil. These can help improve heart health and provide satiety.

- Regular Meals : It's important to eat regular meals and snacks throughout the day to maintain steady blood sugar levels. This can help prevent spikes and crashes in blood glucose.

- Consult a Healthcare Professional : Work with a registered dietitian or diabetes educator to create a personalized meal plan that takes into account your specific needs, preferences, and any other health conditions you may have.

Remember, it's essential to consult with your healthcare provider for personalized advice and guidance on managing your diabetes through diet.